Restylane Refyne

A next-generation hyaluronic acid dermal filler designed to help support your skin while keeping you looking like you

NEW Restylane® Refyne is designed with XpresHAn Technology™ to help soften laugh lines (nasolabial folds and marionette lines). This can help you restore a more natural look to your face while maintaining your facial expressions.1,2 So, you always look like you. Talk to your specialist and see for yourself why it’s worth it.

What is Restylane Refyne?

As skin loses elasticity with age, the lines that run from the sides of your nose toward the corners of your mouth (nasolabial folds) and the lines that run from the corner of your mouth toward the chin (marionette lines) appear more noticeable. Restylane Refyne is a specifically formulated hyaluronic acid dermal filler made with XpresHAn Technology™ that helps correct these lines for a more natural look to your face.3† The unique cross-linking of the gel in Restylane Refyne is also designed to help support your natural expression—for real-life results that help maintain natural movement when you're smiling, frowning and even puckering up.

See the real results

In a clinical study, subjects were evaluated based on perception of the naturalness of facial expressions in motion after 1 month of Restylane Defyne and Restylane Refyne optimal treatment.

Restylane Defyne and Restylane Refyne are the only fillers on the market that have been shown in clinical trials to help maintain natural movement and expressions.

Restylane Refyne Before & After

Treated with 2.5 mL of Restylane Refyne in the laugh lines (nasolabial folds and marionette lines). 2 weeks after treatment.

How long do Restylane treatments last?

In a clinical study of subjects treated for laugh lines with Restylane Refyne and Restylane Defyne, investigators reported improvement in the appearance of wrinkles for up to 12 months in the majority of patients. Using the Wrinkle Severity Rating Scale (WSRS), a validated 5-point measure of the size and depth of the wrinkles, with grade 1 defined as absence of wrinkles and grade 5 as extremely deep and long wrinkles, investigators reported that 79% of Restylane Refyne subjects and 77% of Restylane Defyne subjects had at least a 1-grade improvement on the WSRS after 6 weeks. Subjects also performed self-assessments (SSA) of wrinkle severity, with most reporting at least a 1-grade improvement in SSA scores with Restylane Refyne and with Restylane Defyne after 6 weeks.

How long does it take Restylane treatments to work?

Depending on your volume needs, most Restylane treatment appointments last less than an hour and begin to work almost immediately by adding volume to smooth away wrinkles. A clear gel formulation of hyaluronic acid, Restylane products act like your body's own hyaluronic acid (and eventually break down naturally). Each Restylane product is designed for a specific purpose.

What are the side effects of Restylane products?

After your treatment, you may experience side effects, such as swelling, redness, pain, bruising, headache and itching at injection site and tenderness. These are typically mild in severity and normally last less than 7 days in nasolabial folds and less than 14-18 days in lips. Patients should be limited to 6.0 mL per treatment of moderate to severe facial wrinkles and folds. Swelling may be more likely in patients under 36 years, and bruising may be more likely in patients over 35 years.

How many treatments of Restylane products are needed?

Initial Restylane treatments are usually complete in one or two sessions, as needed. Depending on your individual body chemistry, you will work with your specialist to determine a maintenance schedule. Talk to your physician or healthcare professional about your individual needs.

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